I see no reason why not. The rules contain an option to build units using a 1:20 rather than a 1: 40 figure ratio, which would give you a 40-man Prussian battalion. You can mark off casualties on a roster sheet (an example is provided in the rules), so there's no reason why it wouldn't work perfectly well. In the optional rules there's also a suggestion for using "DKK" with 6-10mm figures, where you treat each base as equivalent to - say - four figures, rather than however many are on your base, and use the rules as they stand, with a typical battalion consisting of 4-6 such bases, just as they would for 15 or 28mm figures. The only difference is that you've got a lot more "real" figures on each base. The same section also provides tables of ranges and move distances etc. for the smaller scales.
Eight days until the rules come out!
Best Wishes,
Angus Konstam
www.edinburghwargames.com